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First Case of 2019 Novel Coronavirus in the United States

Michelle Holshue, Chas DeBolt, Scott Lindquist, Kathy Lofy, John Wiesman, Hollianne Bruce, Christopher Spitters, Keith M. Marzilli Ericson, Sara Wilkerson, Ahmet Tural, George Diaz, Amanda Cohn, LeAnne M. Fox, Anita Patel, Susan I. Gerber, Lindsay Kim, Suxiang Tong, Xiaoyan Lu, Steve Lindstrom, Mark A. Pallansch, William C. Weldon, Holly M. Biggs, Timothy M. Uyeki, Satish K. Pillai • 2020

An outbreak of novel coronavirus (2019-nCoV) that began in Wuhan, China, has spread rapidly, with cases now confirmed in multiple countries. We report the first case of 2019-nCoV infection confirmed in the United States...

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Pfam: The protein families database in 2021

Jaina Mistry, Sara Chuguransky, Lowri Williams, Matloob Qureshi, Gustavo A Salazar, Erik L. L. Sonnhammer, Silvio C. E. Tosatto, Lisanna Paladin, Shriya Raj, Lorna Richardson, ROBERT FINN, Alex Bateman • 2020

Abstract The Pfam database is a widely used resource for classifying protein sequences into families and domains. Since Pfam was last described in this journal, over 350 new families have been added in Pfam 33.1 and nume...

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Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in <i>Phenix</i>

Dorothée Liebschner, Pavel V. Afonine, Matthew L. Baker, Gàbor Bunkòczi, Vincent B. Chen, Tristan I. Croll, Bradley J. Hintze, Li‐Wei Hung, Swati Jain, Airlie J. McCoy, Nigel W. Moriarty, Robert D. Oeffner, Billy K. Poon, Michael G. Prisant, Randy J. Read, Jane S. Richardson, David Richardson, Massimo Sammito, Oleg V. Sobolev, Duncan H. Stockwell, Thomas C. Terwilliger, Alexandre Urzhumtsev, Lizbeth L. Videau, Christopher J. Williams, Paul D. Adams • 2019

Diffraction (X-ray, neutron and electron) and electron cryo-microscopy are powerful methods to determine three-dimensional macromolecular structures, which are required to understand biological processes and to develop n...

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The IntCal20 Northern Hemisphere Radiocarbon Age Calibration Curve (0–55 cal kBP)

Paula Reimer, William E. N. Austin, Édouard Bard, Alex Bayliss, Paul G. Blackwell, Christopher Bronk Ramsey, Martin Butzin, Hai Cheng, R. Lawrence Edwards, Michael Friedrich, Pieter Meiert Grootes, T. P. Guilderson, Irka Hajdas, Timothy Heaton, Alan Hogg, Konrad A Hughen, Bernd Kromer, Sturt W. Manning, Raimund Muscheler, Jonathan Palmer, Charlotte Pearson, J. van der Plicht, Ron Reimer, David A. Richards, E. M. Scott, John Southon, Chris Turney, Lukas Wacker, Florian Adolphi, Ulf Büntgen, Manuela Capano, Simon Fahrni, Alexandra Fogtmann-Schulz, Ronny Friedrich, Peter Köhler, Sabrina G K Kudsk, Fusa Miyake, Jesper Olsen, Frederick Reinig, Minoru Sakamoto, Adam Sookdeo, Sahra Talamo • 2020

Radiocarbon (C) ages cannot provide absolutely dated chronologies for archaeological or paleoenvironmental studies directly but must be converted to calendar age equivalents using a calibration curve compensating for flu...

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UniProt: the universal protein knowledgebase in 2021

Alex Bateman, María Martín, Sandra Orchard, Michele Magrane, Rahat Agivetova, Shadab Ahmad, Emanuele Alpi, Emily Bowler-Barnett, Ramona Britto, Borisas Bursteinas, Hema Bye‐A‐Jee, Ray Coetzee, Austra Cukura, Alan Da Silva, Paul Denny, Tunca Doğan, ThankGod E. Ebenezer, Jun Fan, Leyla Jael Castro, Penelope Garmiri, George P. Georghiou, Leonardo Jose da Costa Gonzales, Emma Hatton-Ellis, Abdulrahman Hussein, Alexandr Ignatchenko, Giuseppe Insana, Rizwan Ishtiaq, Petteri Jokinen, Vishal Joshi, Dushyanth Jyothi, Antonia Lock, Rodrigo López, Aurélien Luciani, Jie Luo, Yvonne Lussi, Alistair MacDougall, Fábio Madeira, Mahdi Mahmoudy, M. Menchi, Alok Mishra, Katie Moulang, Andrew Nightingale, Carla Susana Oliveira, Sangya Pundir, Guoying Qi, Shriya Raj, Daniel L Rice, M. Rodríguez-López, Rabie Saidi, J. H. Sampson, Tony Sawford, Elena Speretta, E. B. Turner, Nidhi Tyagi, Preethi Vasudev, Vladimir Volynkin, Kate Warner, Xavier Watkins, Rossana Zaru, Hermann Zellner, Alan Bridge, Sylvain Poux, Nicole Redaschi, Lucila Aimo, Ghislaine Argoud‐Puy, Andrea H Auchincloss, Kristian B. Axelsen, Parit Bansal, Delphine Baratin, Marie-Claude Blatter, Jerven Bolleman, Emmanuel Boutet, Lionel Breuza, Cristina Casals‐Casas, Leyla Jael Castro, Kamal Chikh Echioukh, Elisabeth Coudert, Beatrice Cuche, Mikael Doche, Dolnide Dornevil, Anne Estreicher, Maria Livia Famiglietti, Marc Feuermann, Elisabeth Gasteiger, Sébastien Géhant, Vivienne Baillie Gerritsen, Arnaud Gos, Nadine Gruaz-Gumowski, Ursula Hinz, Chantal Hulo, Nevila Hyka‐Nouspikel, Florence Jungo, G. Keller, Arnaud Kerhornou, V. Lara, Philippe Le Mercier, Damien Lieberherr, Thierry Lombardot, Xavier Martín, Patrick Masson • 2020

The aim of the UniProt Knowledgebase is to provide users with a comprehensive, high-quality and freely accessible set of protein sequences annotated with functional information. In this article, we describe significant u...

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Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

Manli Wang, Ruiyuan Cao, Leike Zhang, Xing‐Lou Yang, Jia Liu, Mingyue Xu, Zheng‐Li Shi, Zhìhóng Hú, Wu Zhong, Gengfu Xiao • 2020

In December 2019, a novel pneumonia caused by a previously unknown pathogen emerged in Wuhan, a city of 11 million people in central China.The initial cases were linked to exposures in a seafood market in Wuhan. 1 As of...

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Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China

Ling Mao, Huijuan Jin, Mengdie Wang, Yu Hu, Shengcai Chen, Quanwei He, Jiang Chang, Candong Hong, Yifan Zhou, David Wang, Xiaoping Miao, Yanan Li, Bo Hu • 2020

The outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China, is serious and has the potential to become an epidemic worldwide. Several studies have described typical clinical manifestations including fever, cough...

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