Bibliographic record
Advancing curation of viral life cycles, host interactions, and therapeutics in Reactome
- Authors
- Lisa Matthews, Justin Cook, Ralf Stephan, Marija Milacic, Karen Rothfels, Veronica Shamovsky, Bijay Jassal, Robin Haw, Cristoffer Sevilla, Chuqiao Gong, Eliot Ragueneau, Bruce May, Adam Wright, Joel Weiser, Deidre Beavers, Krishna Tiwari, Andrea Senff-Ribeiro, Thawfeek Varusai, Henning Hermjakob, Peter D'Eustachio, Guanming Wu, Lincoln Stein, Marc E. Gillespie
- Publication year
- 2025
- OA status
- hybrid
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Abstract
ABSTRACT Reactome (reactome.org) is a manually curated, peer-reviewed, open-source, open-access pathway knowledgebase of essential human cellular functions. Reactome includes viral life cycles that capture a broad range of virus-induced human pathology. Here, we describe a workflow using collaborative curation strategies, orthoinference procedures, and literature triage to rapidly create reliable molecular models of emergent viruses. The resulting pathway data set rigorously details viral infection pathways, interactions with normal human biological processes, and potential therapeutic compounds.
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